Cyproterone acetate

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Zhuhai Shuangbojie Technology Co,.Ltd

Business Type:Manufacturer

Country/Region:China

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Product Information

  • Pharmacopeia:CP
  • Shelf Life:18 months
  • Storage:Sealed

Description

High Purity Cyproterone acetate Raw Steroid INN, USAN, BAN, JAN 427-51-0 strogen Steroids Powder

 
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated as CPA, and sold under brand names such as Androcur and Cyprostat, is a synthetic steroide antiandrogen drug with additional progestogen and antigonadotropic properties. Its primary action is to suppress the activity of the androgen hormones such as testosterone and its more potent metabolite dihydrotestosterone (DHT) in the body, effects which it mediates via competitive antagonism of the androgen receptor and inhibition of enzymes in the androgen biosynthesis pathway. The main therapeutic indications of cyproterone acetate are prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality (e.g., as a form of chemical castration), and other conditions in which androgen action maintains the disease process. In addition, it can also be used to treat acne and hirsutism in females, and is a common component in hormone therapy for transsexual women.
 

Product Description
 
1. Cyproterone acetate Details:
English Synonyms: 1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio;1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat;1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate;17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio;20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3;6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4;6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat;6-chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup6)-progesteroneaceta
CAS NO.: 427-51-0
Molecular Formula:C24H29ClO4
Molecular Weight:416.94
Assay: 98%
Quality Standard: EP
Appearance: White crystalline powder
Usage: Anti-androgen for the treatment of men with BPH, and can be used as male contraceptive
Packing:1kg/foil bag
 
2. COA:

Product NameCyproterone AcetateQuantity130kg
Batch No140401Packing
Produce Date2017.07.01Report Date2017.07.02
DescriptionWhite or almost white Crystalline Powder
Ref.StandardEP6 Standard
Results of Analysis Tests
TestAnalysis StandardResults of Analysis
IdentificationRequirements StandardConform
Melting PointAbout 210210.5
Specific Rotation+152°~+157°+155°
Loss On Drying≤0.5%0.24%
Related Substance by HPLC≤0.5%
Not more than 0.5%
0.3%
Assay97.0-103.0%99.8%
Sulphate ash≤0.1%
Not more than 0.1%
0.035%
ConclusionThe specification conform with EP6

 

3. Cyproterone acetate Related Products:
Eplerenone CAS: 107724-20-9
Progesterone CAS: 57-83-0
Medroxyprogesterone Acetate CAS: 71-58-9
Ethisterone CAS : 434-03-7
Norethisterone CAS: 68-22-4
Ethynyl estradiol CAS: 57-63-6
Ethynodiol diacetate CAS: 297-76-7
Chlormadinone acetate CAS.: 302-22-7
Cyproterone acetate CAS.: 427-51-0
Estradiol CAS: 50-28-2
17alpha-Oestradiol CAS: 57-91-0
Estradiol Cypionate CAS: 313-06-4
Estradiol valerate CAS: 979-32-8
Estradiol Benzoatae CAS:50-50-0
Estrone CAS: 53-16-7
Estriol CAS: 50-27-1
19-Norethindrone acetate CAS:51-98-9
Norethisterone enanthate CAS:3836-23-5
Megestrol acetate CAS.: 595-33-5
Estradiol enantate CAS: 4956-37-0

 

Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated as CPA, and sold under brand names such as Androcur and Cyprostat, is a synthetic steroide antiandrogen drug with additional progestogen and antigonadotropic properties. Its primary action is to suppress the activity of the androgen hormones such as testosterone and its more potent metabolite dihydrotestosterone (DHT) in the body, effects which it mediates via competitive antagonism of the androgen receptor and inhibition of enzymes in the androgen biosynthesis pathway. The main therapeutic indications of cyproterone acetate are prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality (e.g., as a form of chemical castration), and other conditions in which androgen action maintains the disease process. In addition, it can also be used to treat acne and hirsutism in females, and is a common component in hormone therapy for transsexual women.
In addition to its antiandrogen properties, cyproterone acetate has weak progestogen activity (i.e., it acts like progesterone). Accordingly, it can be used to treat hot flashes, and is also a component of some combined oral contraceptive pills such as Dianette in the United Kingdom and Diane-35 in other countries such as Canada. It is called Dixi-35 in Chile. No form of cyproterone acetate is available in the United States.
Until the development of leuprorelin, cyproterone acetate was one of the few drugs used to treat precocious puberty. It was also used in animal experimentation to investigate the actions of androgens in fetal sexual differentiation.
 

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